Which demographic is most likely to develop multiple myeloma?

The risk of developing multiple myeloma increases as people get older. Most cases occur in people who are at least 65 years old . The average age of people diagnosed with multiple myeloma is between 66 and 70 years old . About 37% of people with multiple myeloma are younger than 65 at the time of diagnosis.

Who is most at risk for developing multiple myeloma?

Who develops multiple myeloma?

Age is the most significant risk factor for developing myeloma. People younger than 45 years old rarely develop the disease. Men are more likely than women to develop myeloma, and myeloma is more than twice as common among Black people as among White people.

What age is myeloma most common?

adults over 60 – most cases are diagnosed at around the age of 70, and cases affecting people under the age of 40 are rare. black people – multiple myeloma is about twice as common in black populations than white and Asian populations.

Why are men more likely to develop multiple myeloma?

Women have a lower risk of developing myeloma, and are more likely to develop myeloma as a result of aberrant class switch recombination events. Conversely, men have a higher risk of developing myeloma, and are more likely to develop myeloma as a result of hyperdiploidy.

Dr. Edward Libby Shares Facts about Multiple Myeloma

In what ethnic group is more frequent multiple myeloma?

African Americans (AAs) have a higher incidence of multiple myeloma (MM) than White patients. Mortality is also higher in AAs compared with White patients. AAs more commonly have immunoglobulin H translocations t(11;14) and t(14;16) compared with White patients.

What triggers myeloma?

What Are Its Causes? Exposure to toxic chemicals, atomic radiation, anything that interferes with the immune system, or infection with cancer-causing viruses, may potentially be linked to the developing myeloma.

Does obesity cause multiple myeloma?

Obesity is increasingly associated with the transformation of monoclonal gammopathy of undetermined significance (MGUS) into multiple myeloma (MM). Obesity, MGUS, and MM share common etiopathogenesis mechanisms including altered insulin axis and the action of inflammatory cytokines.

Can stress cause multiple myeloma?

Stress can be a very destructive force when it comes to myeloma. Stress really disrupts the immune system and myeloma is a cancer of the immune system. In addition, the stress hormone noradrenaline (the "flight" hormone, versus adrenaline, the "fight" hormone) can actually trigger cancer cell growth directly.

What are some healthy habits a person can follow to avoid multiple myeloma?

What precedes multiple myeloma?

Recent data indicate that multiple myeloma is consistently preceded by the precursor states of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma.

What is usually the first symptom of multiple myeloma?

Multiple myeloma causes many symptoms, but bone pain often is the first symptom people notice. Other symptoms include: Weakness in your arms and legs and/or a sensation of numbness in your arms and legs. Multiple myeloma can affect the bones in your spine, causing them to collapse and press on your spinal cord.

How is multiple myeloma usually found?

It is usually found on a routine blood test when looking for other conditions. Although people with multiple myeloma have a monoclonal gammopathy, not everyone with monoclonal gammopathy has multiple myeloma. It can also occur in other diseases, such as Waldenstrom macroglobulinemia and some lymphomas.

How can you reduce the risk of multiple myeloma?

Does smoking cause multiple myeloma?

Smoking does not appear to be a risk factor for multiple myeloma. Cigarette smoking is not a risk factor for multiple myeloma, according to the results of a pooled analysis of nine case-control studies published in Cancer Epidemiology, Biomarkers & Prevention.

Does myeloma run in families?

Family history

Those with a parent, brother, sister, or child with myeloma or monoclonal gammopathy of unknown significance (MGUS) are 2 or 3 times as likely to develop myeloma or MGUS compared to people with no close family members with these illnesses.

What is the most prominent symptom of multiple myeloma?

Major symptoms of multiple myeloma may include bone pain, especially in the back and the ribs; low levels of circulating red blood cells (anemia) resulting in weakness, fatigue, and lack of color (pallor); and kidney (renal) abnormalities.

What are the red flags for multiple myeloma?

High blood levels of calcium

Extreme thirst, leading to drinking a lot. Urinating (peeing) a lot. Dehydration. Kidney problems and even kidney failure.

Can multiple myeloma be prevented?

With multiple myeloma, few cases are linked to risk factors that can be avoided, so there is no known way to prevent most multiple myelomas from developing.

Can Diet Cure multiple myeloma?

There aren't any proven diets to treat multiple myeloma. However, there are specific nutritional strategies that you can use to treat common symptoms, that occur while being treated with multiple myeloma, as well as to reduce a cancer recurrence.

What are the two major cause of death in multiple myeloma?

To conclude, the majority of transplant-eligible MM patients died MM-dependent, with one-fifth of these cases caused by therapeutic side effects. Infections, SPM and GvHD were the most common therapy-related COD. Among MM progression-related COD infections, renal failure and cardiopulmonary failure were leading.

What is the most frequent cause of death in a patient with multiple myeloma?

Infection is a major complication and a leading cause of death in patients with multiple myeloma (MM) [1]. The risk of infection is due to a multifactorial immunodeficiency caused by the disease itself and the treatment regimens given during the different phases of therapy [2].

Can b12 deficiency cause multiple myeloma?

There are studies that have shown a correlation between vitamin b12 deficiency and multiple myeloma as a marker of disease severity.

Does myeloma show up in blood test?

Laboratory analysis of your blood may reveal the M proteins produced by myeloma cells. Another abnormal protein produced by myeloma cells — called beta-2-microglobulin — may be detected in your blood and give your doctor clues about the aggressiveness of your myeloma.

How quickly can myeloma develop?

The risk of myeloma progressing is highest in the first 5 years after diagnosis. About 50 out of 100 people (50%) with smouldering myeloma develop symptoms and need treatment within the first 5 years. However, after 5 years the risk decreases and some people never develop symptoms or need treatment.