What is the first stage of myeloma?

This earliest phase is called smoldering multiple myeloma. When you have it, you won't have any symptoms, but your test results will show: At least 10% to 59% of your bone marrow is made up of cancerous plasma cells. You have the abnormal antibodies that myeloma cells make in your blood or urine.

What is the life expectancy of Stage 1 multiple myeloma?

The median length of survival after diagnosis with multiple myeloma is 62 months for Stage I, 44 months for Stage II, and 29 months for Stage III. Life expectancy depends on many factors, including the person's age, health, kidney function, and more.

What are the symptoms of multiple myeloma Stage 1?

  • Bone pain, especially in your spine or chest.
  • Nausea.
  • Constipation.
  • Loss of appetite.
  • Mental fogginess or confusion.
  • Fatigue.
  • Frequent infections.
  • Weight loss.

What is stage1 myeloma?

The ISS divides myeloma into 3 stages: Stage 1 means: the level of the protein called beta 2 microglobulin (ß2-microglobulin or ß2-M) is less than 3.5 milligrams per litre (mg/L)​ the level of albumin in the blood is more than 3.5 grams per decilitre (g/dL)

How serious is Stage 1 multiple myeloma?

Stage 1 (or stage I) multiple myeloma is the least advanced stage. People with stage 1 myeloma have few myeloma cells in the body. The cancer cells have not yet spread very far or caused as much damage as in other stages.

What Are The Stages Of Multiple Myeloma?

Can you lead a normal life with myeloma?

Apart from ongoing monitoring, most myeloma patients are able to live fairly normal lives, with few restrictions on low-impact exercise and other activity.

What triggers myeloma?

What Are Its Causes? Exposure to toxic chemicals, atomic radiation, anything that interferes with the immune system, or infection with cancer-causing viruses, may potentially be linked to the developing myeloma.

Can Stage 1 myeloma be cured?

Treatment for multiple myeloma can often help control symptoms and improve quality of life. But myeloma usually can't be cured, which means additional treatment is needed when the cancer comes back.

Where does myeloma spread to first?

At first, the cells reproduce in the bone marrow of the spine. From there, they enter the bloodstream and travel to bone marrow in other parts of the body. They collect in the bone marrow and the hard, outer part of the bones. As this progression happens, the plasma cells can cause multiple tumors.

What are the symptoms of stage 2 multiple myeloma?

Signs and Symptoms of Stage 2 Multiple Myeloma
  • Bone pain.
  • Extreme tiredness.
  • High levels of calcium in the blood.
  • Anemia (low levels of red blood cells)
  • Thrombocytopenia (low platelet counts)
  • Decreased kidney function.
  • Bone lesions (abnormalities or bone damage)
  • Frequent infections.

How fast does multiple myeloma spread?

How quickly multiple myeloma progresses can vary between people. An older 2007 study of 276 people found that there was a 10% risk of progression in people with early multiple myeloma per year for the first 5 years of illness.

Does myeloma show up in blood test?

Laboratory analysis of your blood may reveal the M proteins produced by myeloma cells. Another abnormal protein produced by myeloma cells — called beta-2-microglobulin — may be detected in your blood and give your doctor clues about the aggressiveness of your myeloma.

What is the treatment for Stage 1 multiple myeloma?

Patients with active myeloma or light chain amyloidosis are often given a combination of 2 or 3 drugs. The drugs chosen depend on the patient's health (including their kidney function) and whether a stem cell transplant is planned. Often, a combination containing bortezomib, lenalidomide, and dexamethasone is used.

Can you live 30 years with myeloma?

While multiple myeloma doesn't yet have a cure and can be fatal, patients' life expectancies vary widely, according to Jens Hillengass, MD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center. “I have seen patients live from several weeks to more than 20 years after being diagnosed,” Dr. Hillengass says.

Can multiple myeloma be stopped?

There is no known way to prevent multiple myeloma from developing in those people with monoclonal gammopathy of undetermined significance or solitary plasmacytomas. Research is investigating if treating certain high risk smoldering multiple myeloma may keep it from becoming active multiple myeloma.

Is myeloma always terminal?

Treatment for myeloma can be very effective at controlling the disease, relieving its symptoms and complications, and prolonging life. Unfortunately, though, myeloma is currently an incurable (terminal) cancer. Myeloma is a relapsing-remitting cancer.

How do you know what stage of myeloma you have?

Multiple myeloma is staged using the Revised International Staging System (RISS) based on 4 factors:
  1. The amount of albumin in the blood.
  2. The amount of beta-2-microglobulin in the blood.
  3. The amount of LDH in the blood.
  4. The specific gene abnormalities (cytogenetics) of the cancer.

What bones does multiple myeloma affect first?

Back pain is often the first symptom of multiple myeloma. Because back problems are common, they might not initially be associated with the disease. However, a backache that lasts for months can be a signal that multiple myeloma is affecting the bones in the spine or ribs.

What organ is most affected by multiple myeloma?

Multiple myeloma, also known as myeloma, is a type of bone marrow cancer. Bone marrow is the spongy tissue found at the centre of some bones. It produces the body's blood cells. Multiple myeloma affects the plasma cells (a type of blood cell) inside the bone marrow.

Can myeloma heal on its own?

There's no cure, but treatments can slow its spread and sometimes make symptoms go away. A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multiple myeloma, these cells multiply the wrong way.

How long is chemo for myeloma?

Myeloma is not usually curable but treatment can control it. You usually have treatment for four to six months. Then if you are fit enough, your specialist might suggest intensive treatment using high dose chemotherapy with a stem cell transplant.

Does myeloma affect the brain?

It can slow blood flow to the brain and cause: Confusion. Dizziness. Symptoms of a stroke, like weakness on one side of the body and slurred speech.

Can myeloma be caused by stress?

Stress can be a very destructive force when it comes to myeloma. Stress really disrupts the immune system and myeloma is a cancer of the immune system. In addition, the stress hormone noradrenaline (the "flight" hormone, versus adrenaline, the "fight" hormone) can actually trigger cancer cell growth directly.

What part of the body does myeloma affect?

Myeloma affects areas where you have active bone marrow. This includes your arms and legs and your shoulders as well as your spine, skull, pelvis and rib cage. Myeloma affects several places in the body which is why it is sometimes called multiple myeloma.

Who is prone to myeloma?

Myeloma occurs most commonly in people over 60. The average age at diagnosis is 70. Only 2% of cases occur in people under 40.