What drug should not be taken with clopidogrel?

Medications like proton pump inhibitors (PPIs), fluoxetine (Prozac), and fluconazole (Diflucan) can make clopidogrel less effective. Grapefruit juice can also make clopidogrel less effective. Taking clopidogrel with certain medications can increase your risk of bleeding.


What medications should not be taken with clopidogrel?

Clopidogrel may interact with other medications
  • Diabetes drug. In most cases, repaglinide should not be taken with clopidogrel. ...
  • Stomach acid drugs (proton pump inhibitors) ...
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) ...
  • Blood thinners.
  • Drugs used to treat depression. ...
  • Salicylates (aspirin) ...
  • Opioids.


What is the most serious adverse effect of clopidogrel?

This medicine may cause allergic reactions, including angioedema, which can be life-threatening and require medical attention. Check with your doctor right away if you have large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs.


When should you not take clopidogrel?

Clopidogrel must not be given to anyone under 18 years old, unless under specialist advice. It's also not recommended if you're pregnant or breastfeeding. Your doctor or dentist may advise you to stop taking clopidogrel for a short time before a procedure or dental treatment.

What should I watch for clopidogrel?

Clopidogrel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • excessive tiredness.
  • headache.
  • dizziness.
  • nausea.
  • vomiting.
  • stomach pain.
  • diarrhea.
  • nosebleed.


Clopidogrel Side Effects, Drug Interactions and Uses | Plavix Side Effects



Is it better to take clopidogrel in the morning or at night?

Platelet aggregation induced by two inducers was significantly higher at 10:00 in day-time group compared to values in night-time group (all P < 0.05). Conclusion: Taking aspirin and clopidogrel at 20:00 was superior to taking the same medications at 8:00 for inhibiting peak platelet aggregation in the morning.

What is the black box warning for clopidogrel?

The Boxed Warning is about patients who do not effectively metabolize the drug (i.e. "poor metabolizers") and therefore may not receive the full benefits of the drug. The Boxed Warning in the drug label will include information to: Warn about reduced effectiveness in patients who are poor metabolizers of Plavix.

How long should a patient take clopidogrel?

Some people take these medications for up to 12 months after a heart attack or stent placement, and even longer in some cases. If you've had a heart attack and are taking Plavix and aspirin, talk with your healthcare provider about how long you'll need to take these medications.


How do you know if clopidogrel is working?

You may notice that you bruise or bleed more easily and it will take longer to stop bleeding while you are taking clopidogrel. This shows that clopidogrel is working.

What medications should not be taken with blood thinners?

Your blood thinner may not work right with them. For example, aspirin, ibuprofen, and naproxen can make you bleed more. Even common products like Pepto-Bismol can cause bleeding.

What vitamins should be avoided when on blood thinners?

If you are a heart patient who is taking blood thinners, such as warfarin (Coumadin®), you need to be careful not to overdo vitamin K.


Is it safe to take omeprazole with clopidogrel?

Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.

Does clopidogrel affect sleep?

The organic nitrates (isosorbide) and the antiplatelet agents (acetylsalicylic acid, clopidogrel) are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.

How many hours does clopidogrel last?

A single, oral dose of Plavix (clopidogrel) 75 mg has a half-life of approximately 6 hours. It takes 5.5 x half-life of a medicine for a drug to leave the body, therefore most of the Plavix should be eliminated from your system in 5.5 x 6 = 33 hours.


Can you have a stroke while on clopidogrel?

Intracranial hemorrhages occurred in 5 patients (0.2%) receiving clopidogrel plus aspirin and in 2 patients (0.1%) receiving aspirin. All of these were hemorrhagic strokes.

Why is clopidogrel stopped after a year?

Among patients with MI, clopidogrel discontinuation within the first month after coronary stent implantation has been associated with a 9-fold increased risk of death by 12 months [20]. Discontinuation within the first year, particularly within the first month, has been associated with adverse events [21].

Does clopidogrel make you tired?

Objective: Clopidogrel is a commonly used antiplatelet agent for the prevention of thromboembolic complications following neuroendovascular procedures, but anecdotal data have raised concern for the possibility that clopidogrel may induce severe, intolerable fatigue.


What is the best time of day to take clopidogrel 75 mg?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

Is clopidogrel hard on the liver?

The severity of liver injury associated with clopidogrel ranges from transient, mild serum enzyme elevations to clinically apparent acute hepatitis that can be severe and lead to death. Most cases resolve with drug withdrawal within 1 to 3 months.

What happens when you stop taking clopidogrel?

In multivariable analysis, the 0- to 90-day interval after stopping clopidogrel was associated with higher risk of death/MI (incidence rate ratio, 2.74; 95% confidence interval, 1.69 to 4.44) compared with 91- to 360-day interval.


Why do some people not respond to clopidogrel?

Some people with clopidogrel resistance have a reduced ability to convert the drug to its active form because of a polymorphism in one copy of the CYP2C19 gene that results in decreased enzyme activity. These individuals are described as intermediate metabolizers.

Do you gain weight with clopidogrel?

Weight changes, including weight loss, are not commonly seen with Plavix. However, Plavix has been shown to cause loss of taste in a few individuals within the first two to eight weeks of taking the medication.

Can I drink coffee while taking clopidogrel?

These medications are used to slow blood clotting and include aspirin, clopidogrel (Plavix), ibuprofen (Advil, Motrin, and others), naproxen (Anaprox, Naprosyn, and others), enoxaparin (Lovenox), and more. Health experts advise caution when combining them with coffee, which can also slow blood clotting.


Does clopidogrel cause joint pain?

Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pains following initiation of therapy with clopidogrel. Acute-phase reactants were elevated.

Can clopidogrel cause memory problems?

What should I go over with my doctor? Some patients have no side effects, have had very good results with Plavix and even credit it with saving their lives. Others have had many different side effects, bruising, uncontrollable bleeding, memory loss, fatigue, swelling of hands and feet and many more.
Previous question
Is milk good for epilepsy?
Next question
What will shrink a cyst?