What does anastrozole do to your bones?

Purpose: The aromatase inhibitor anastrozole is a highly effective well-tolerated treatment for postmenopausal endocrine-responsive breast cancer. However, its use is associated with accelerated bone loss and an increase in fracture risk.


How long does it take for anastrozole to affect bone density?

Anastrozole is associated with accelerated bone loss over the 5-year treatment period.

Does anastrozole cause joint damage?

Many postmenopausal women using anastrozole, known as Arimidex, experience an increased risk of experiencing bone and joint pain. Anastrozole does, in fact, list joint pain and bone loss as potential side effects. It looks as though about 1 in 3 women taking the drug experience this side effect.


Will bone density improve after stopping anastrozole?

Bone loss associated with anastrozole use is partially reversible after stopping treatment, particularly at the lumbar spine. For patients who have been given risedronate for osteoporosis prevention, bone mineral density improved only at the lumbar spine but not the total hip.

What are the long term side effects of anastrozole?

Such long-term use is associated with some anastrozole side effects such as weight gain, osteoporosis, hair loss, and bone fractures. These are typically the result of years of estrogen suppression.


Anastrozole - Mechanism, precautions, interactions & uses



What kind of joint pain does anastrozole cause?

Compared with tamoxifen, aromatase inhibitors (AIs) are associated with higher incidence of arthralgia (joint pain or stiffness). Among patients treated with the third-generation AI anastrozole, the incidence of arthralgia has been reported as greater than 30%.

What foods to avoid while taking anastrozole?

Avoid raw fruits, vegetables, whole-grain breads, cereals, and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea.

Should you take calcium with anastrozole?

No interactions were found between anastrozole and Calcium 600 D. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.


What helps joint pain from anastrozole?

Ways to take care of your joints
  1. Do regular exercise to strengthen the muscles around your joints. This can help to keep them flexible and reduce pain. ...
  2. Acupuncture may help to reduce pain from joint symptoms for some women. ...
  3. Complementary therapies such as massage may be helpful for some women.


Does anastrozole affect your memory?

A pattern of decline in working memory and concentration with initial exposure to anastrozole was observed. Women receiving anastrozole alone had a second deterioration in working memory and concentration from 12 to 18 months after therapy initiation.

Why should I not take anastrozole?

This medicine may increase the chance of heart problems, including heart attack, in women who have a history of ischemic heart disease. This medicine may decrease bone mineral density when used for a long time. A low bone mineral density can cause weak bones or osteoporosis.


Does anastrozole cause belly fat?

Overall, trials have shown no difference in the amount of weight gained between women taking anastrozole and those who were taking tamoxifen or placebo (a pretend pill).

Can anastrozole affect your eyesight?

Based on analysis of OCT retinal thickness data, it is likely that anastrozole increases the tractional force between the vitreous and retina. Consequently, AI users, myopic AI users particularly, might be at increased risk for traction-related vision loss.

Does anastrozole make you weak?

depression, mood changes, problems with your fingers while gripping, or. numbness, tingling, cold feeling, or weakness in your hand or wrist.


Should anastrozole be taken morning or night?

If hot flashes are troublesome: • Take your anastrozole at bedtime. hot flashes continue to bother you. There may be medications available. Muscle or joint pain may occur a few days after your treatment.

How much calcium and vitamin D should I take with anastrozole?

In the new study of 60 patients with breast cancer who had been receiving the AI anastrozole (Arimidex, AstraZeneca) for at least 2 months, all the women took the recommended daily dose of vitamin D2 — 400 IU — plus 1000 mg of calcium a day.

How does anastrozole make you feel?

Common side effects can be like menopause symptoms and include hot flushes, difficulty sleeping, tiredness and low mood. Side effects usually improve after a few months as your body gets used to the medicine. Your doctor will monitor your blood pressure, cholesterol levels and bone density during your treatment.


How do you feel on anastrozole?

What are some other side effects of this drug?
  1. Hot flashes.
  2. Feeling dizzy, tired, or weak.
  3. Headache.
  4. Constipation, diarrhea, stomach pain, upset stomach, throwing up, or decreased appetite.
  5. Heartburn.
  6. Back, muscle, or joint pain.
  7. Joint swelling.
  8. Pelvic pain.


Is anastrozole hard on the liver?

Liver injury attributed to anastrozole is usually mild and self-limited, typically a transient, asymptomatic elevation in serum enzymes. Cases of severe hepatitis have been reported in women on anastrozole, but acute liver failure has not.

Does anastrozole affect your teeth?

5. Does Anastrozole ruin your teeth? While Anastrozole or any other hormone-based cancer therapies do not ruin your teeth or dental problems are not common side effects of this drug, breast cancer survivors and chemotherapy patients must be aware of the risk of tooth decay and other dental problems.


Is anastrozole a form of chemotherapy?

Anastrozole (Arimidex) is considered a hormone therapy rather than a traditional chemotherapy medication. Chemotherapy is used to target and kill cancer cells, whereas anastrozole (Arimidex) is used to lower estrogen in the body. Some breast cancer cells need estrogen to grow.

Does anastrozole raise blood pressure?

In the ATAC trial, anastrozole was associated with higher rates of hypercholesterolemia and hypertension [4].

Why is anastrozole a hazardous drug?

Anastrozole: Remarks: No specific effects reported. May cause damage to organs (Liver, Kidney, Testes, ovaries) through prolonged or repeated exposure if swallowed.


What is the best time of day to take anastrozole?

You may take anastrozole at whatever time of day you find easiest to remember, but try to take your doses at the same time each day. This will help you to avoid missing any doses. You can take the tablet before or after a meal. If you forget to take a dose, take it as soon as you remember.

How long should you be on anastrozole?

Anastrozole is a long term treatment and you usually take it for up to 5 years.