What are symptoms of stage of multiple myeloma?

Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none.
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Symptoms
  • Bone pain, especially in your spine or chest.
  • Nausea.
  • Constipation.
  • Loss of appetite.
  • Mental fogginess or confusion.
  • Fatigue.
  • Frequent infections.
  • Weight loss.


How do you know what stage of multiple myeloma you are in?

Staging multiple myeloma is based on the results of blood and imaging tests. Results of other tests can also help determine the stage depending on the system used. Doctors use 2 systems to stage multiple myeloma: International Staging System (ISS)

What are the symptoms of stage 2 multiple myeloma?

Signs and Symptoms of Stage 2 Multiple Myeloma
  • Bone pain.
  • Extreme tiredness.
  • High levels of calcium in the blood.
  • Anemia (low levels of red blood cells)
  • Thrombocytopenia (low platelet counts)
  • Decreased kidney function.
  • Bone lesions (abnormalities or bone damage)
  • Frequent infections.


What are the symptoms of stage 3 multiple myeloma?

What are symptoms of stage 3 multiple myeloma?
  • nausea.
  • constipation.
  • pain in the bones and back.
  • depression.
  • fatigue.
  • frequent infections.
  • weight loss.
  • bruising.


What are the symptoms of stage 4 multiple myeloma?

But when you have late-stage multiple myeloma, your symptoms may show up as:
  • Being sick to your stomach.
  • Bone pain in your back or ribs.
  • Bruising or bleeding easily.
  • Feeling very tired.
  • Fevers.
  • Frequent infections that are hard to treat.
  • Losing a lot of weight.
  • Not feeling like eating.


What Are The Stages Of Multiple Myeloma?



Where does myeloma spread to first?

At first, the cells reproduce in the bone marrow of the spine. From there, they enter the bloodstream and travel to bone marrow in other parts of the body. They collect in the bone marrow and the hard, outer part of the bones. As this progression happens, the plasma cells can cause multiple tumors.

How fast does myeloma progress?

The risk of myeloma progressing is highest in the first 5 years after diagnosis. About 50 out of 100 people (50%) with smouldering myeloma develop symptoms and need treatment within the first 5 years. However, after 5 years the risk decreases and some people never develop symptoms or need treatment.

Is Stage 2 multiple myeloma serious?

Stage II or III multiple myeloma is characterized by an intermediate or high amount of cancer in the body. Patients with either of these stages of multiple myeloma often have bone complications as a result of their disease and usually experience symptoms that require treatment.


What is usually the first symptom of multiple myeloma?

Multiple myeloma causes many symptoms, but bone pain often is the first symptom people notice. Other symptoms include: Weakness in your arms and legs and/or a sensation of numbness in your arms and legs. Multiple myeloma can affect the bones in your spine, causing them to collapse and press on your spinal cord.

Can Stage 3 multiple myeloma be cured?

People do not often experience multiple myeloma symptoms until they reach stage 3. At this stage, the cancer affects multiple areas of the body, causing complex symptoms. There is currently no cure for multiple myeloma, but treatment is available.

What is the difference between Stage 1 and Stage 2 multiple myeloma?

Stage 1 indicates early multiple myeloma that does not cause symptoms, stage 2 shows intermediate disease and may cause symptoms, and stage 3 is the most advanced stage of multiple myeloma, which means the cancer has spread to other parts of the body.


What makes multiple myeloma worse?

Factors such as older age and other health conditions can also make multiple myeloma harder to treat and lead to a worse outlook. There is no cure for myeloma, although treatments can often help keep the cancer under control for many years.

Where does your back hurt with multiple myeloma?

Bone pain is a common symptom. Myeloma cells grow in the bone marrow and cortical bone, causing local bone damage or generalized thinning of the bone, which is called osteoporosis. This makes the bone more likely to break. The back or ribs are the most common sites of bone pain, but any bone can be affected.

What is the most common complication of multiple myeloma?

Common complications that can occur as a result of multiple myeloma include:
  • Hypercalcemia (elevated calcium levels in the blood)
  • Kidney problems.
  • Anemia (low red blood cell counts)
  • Bone problems, such as osteoporosis, bone pain, and fractures.


What triggers myeloma?

What Are Its Causes? Exposure to toxic chemicals, atomic radiation, anything that interferes with the immune system, or infection with cancer-causing viruses, may potentially be linked to the developing myeloma.

What comes before multiple myeloma?

A precancerous condition called monoclonal gammopathy of undetermined significance (MGUS) A single tumor of plasma cells (solitary plasmacytoma) Smoldering myeloma, a precancerous condition that affects the plasma cells and can turn into multiple myeloma.

Do you sleep a lot with myeloma?

People living with multiple myeloma can feel extremely tired even if they're getting enough sleep. This condition is called fatigue. It's important to recognize the symptoms of fatigue and to report those symptoms to your healthcare team.


What is the number one cause of multiple myeloma?

It's not known exactly what causes multiple myeloma. However, there is a close link between multiple myeloma and a condition called monoclonal gammopathy of unknown significance (MGUS). MGUS is where there is an excess of protein molecules, called immunoglobulins, in your blood.

What are the red flags for multiple myeloma?

Numbness: most commonly found within the spine, due to vertebrae weakening. Kidney problems: damage or failure due to unnecessary pressure on kidneys. Hypercalcemia: high calcium content in blood because of bone breakdown. Can lead to exhaustion, constipation and kidney issues.

Is Stage 2 myeloma curable?

But myeloma usually can't be cured, which means additional treatment is needed when the cancer comes back. Not everyone diagnosed with myeloma needs immediate treatment – for example, the condition may not be causing any problems. This is sometimes referred to as asymptomatic or smouldering myeloma.


What stage is high risk multiple myeloma?

Stage 3 characteristics: Beta-2 microglobulin is 5.5 mg/L or higher. Cytogenetics show chromosomal changes in the myeloma cells that are high risk and/or lactate dehydrogenase levels are high.

Can you live a normal life with myeloma?

Apart from ongoing monitoring, most myeloma patients are able to live fairly normal lives, with few restrictions on low-impact exercise and other activity.

What is the life expectancy of a person with multiple myeloma?

As myeloma treatments are advancing, people have more hope in managing the disease. “About 20 years ago, the life expectancy was about three years, and overall now it is at least five to six years,” says Bartlett.


Does myeloma affect the brain?

It can slow blood flow to the brain and cause: Confusion. Dizziness. Symptoms of a stroke, like weakness on one side of the body and slurred speech.

How Long Can multiple myeloma go untreated?

While multiple myeloma doesn't yet have a cure and can be fatal, patients' life expectancies vary widely, according to Jens Hillengass, MD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center. “I have seen patients live from several weeks to more than 20 years after being diagnosed,” Dr. Hillengass says.