Can you have high platelets with multiple myeloma?

Conclusions: Platelet reactivity is increased in multiple myeloma and increased further upon iMiD treatment.


Does multiple myeloma cause high platelets?

Multiple myeloma can also cause the level of platelets in the blood to become low (called thrombocytopenia). This can lead to increased bleeding and bruising. Another condition that can develop is leukopenia (a shortage of normal white blood cells).

What cancer makes your platelets high?

A recent increase in the platelet count was associated with risk of colon cancer (OR, 5.52; 95% CI, 5.21-5.86), lung cancer (OR, 4.77; 95% CI, 4.51-5.04), ovarian cancer (OR, 7.23; 95% CI, 6.12-8.53), and stomach cancer (OR, 5.51; 95% CI, 4.82-6.29) (Figure 3 and eTable 7 in the Supplement).


What shows up in blood with multiple myeloma?

Finding a monoclonal antibody in the blood may be the first step in diagnosing multiple myeloma. This abnormal protein is known by several different names, including monoclonal immunoglobulin, monoclonal protein (M protein), M spike, or paraprotein.

What is the most common cause of high platelet count?

Inflammatory conditions like autoimmune diseases, cancer or trauma, as well as certain infections and iron deficiency, are common causes of a high platelet count.


Thrombocytosis (primary and secondary) | Why Is My Platelet Count High?



Should I be worried if my platelet count is high?

If your platelet count is too high, blood clots can form in your blood vessels. This can block blood flow through your body. Thrombocythemia refers to a high platelet count that is not caused by another health condition. This condition is sometimes called primary or essential thrombocythemia.

Can platelets be high for no reason?

Less commonly, when thrombocytosis has no apparent underlying condition as a cause, the disorder is called primary thrombocythemia or essential thrombocythemia. This is a blood and bone marrow disease. Your doctor might detect thrombocytosis in a routine blood test result that shows a high platelet level.

What is the hallmark symptom of multiple myeloma?

The hallmark symptom of multiple myeloma is bone pain. It often occurs in the back, the hips, and sometimes the skull. Some patients may experience pain that is worse at night, which disrupts their sleep. When you have multiple myeloma, your bones may easily break.


What is the most prominent symptom of multiple myeloma?

Major symptoms of multiple myeloma may include bone pain, especially in the back and the ribs; low levels of circulating red blood cells (anemia) resulting in weakness, fatigue, and lack of color (pallor); and kidney (renal) abnormalities.

What is the most important blood test for multiple myeloma?

Complete Blood Count (CBC)

It is one of the most important blood tests used for diagnosing and monitoring myeloma patients. The CBC quantifies all the cells that make up the solid parts of blood. The liquid part of blood that is colorless is called serum. Blood cells are suspended in the serum.

Do platelets go up or down with cancer?

When you have cancer or when you receive treatment for cancer, your levels of certain blood cells can go below normal. Platelets are one of these types of blood cells. The medical terms for a low level of platelets are "low platelet count" or "thrombocytopenia."


Can high platelets be something other than cancer?

Having a high platelet count, or thrombocytosis, doesn't always indicate something serious is going on. Many times, it is linked to a temporary condition or circumstance, such as an infection or recent surgery. However, high platelet levels can be associated with more serious conditions, such as cancer.

What is usually the first early symptom of multiple myeloma?

Multiple myeloma causes many symptoms, but bone pain often is the first symptom people notice. Other symptoms include: Weakness in your arms and legs and/or a sensation of numbness in your arms and legs. Multiple myeloma can affect the bones in your spine, causing them to collapse and press on your spinal cord.

What does a high platelet count indicate?

A high platelet count can occur when something causes the bone marrow to make too many platelets. When the reason is unknown, it is called primary or essential thrombocytosis. When excess platelets are due to an infection or other condition, it is called secondary thrombocytosis.


How do you rule out multiple myeloma?

Bone marrow biopsy

This test is required to confirm the diagnosis of multiple myeloma. A needle is inserted into the bone marrow space to remove a small sliver of bone marrow. Our hematopathologists examine the tissue under a microscope to determine if there are myeloma cells in the bone marrow.

What are the red flags for multiple myeloma?

High blood levels of calcium

Extreme thirst, leading to drinking a lot. Urinating (peeing) a lot. Dehydration. Kidney problems and even kidney failure.

What is the most common complaint of multiple myeloma?

Bone pain is the most common presenting symptom in MM. Most case series report that 70% of patients have bone pain at presentation. The lumbar spine is one of the most common sites of pain. Pathologic fractures are very common in MM; 93% of patients have more than one site of bony involvement.


When should you suspect multiple myeloma?

Multiple myeloma should be considered as a diagnosis in patients over 50 years of age with back pain persisting more than one month if one or more red flags (Table 1) are identified.

Does myeloma show in full blood count?

Tests used to monitor myeloma include: full blood count (FBC) serum protein electrophoresis. immunofixation (in some cases)

What is the gold standard in diagnosing multiple myeloma?

Plain radiography remains the gold standard imaging procedure for staging newly diagnosed and relapsed myeloma, according to an International Myeloma Working Group consensus statement.


Where does your back hurt with multiple myeloma?

The spine and long bones (arms and legs) are most often affected. Fractures of the spine can cause the sections of the spine to collapse, leading to pain and, occasionally, compression of the spinal cord (the main column of nerves running down the back).

How do high platelets make you feel?

Essential thrombocythemia (throm-boe-sie-THEE-me-uh) is an uncommon disorder in which your body produces too many platelets. Platelets are the part of your blood that sticks together to form clots. This condition may cause you to feel fatigued and lightheaded and to experience headaches and vision changes.

How much platelet count is alarming?

A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Having more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is known as thrombocytopenia.


Which is worse high or low platelet count?

Platelets are cells that help your blood clot. Too few platelets can be a sign of cancer, infections or other health problems. Too many platelets put you at risk for blood clots or stroke.

What is alarming level of platelet count?

Dangerous internal bleeding can occur when your platelet count falls below 10,000 platelets per microliter. Though rare, severe thrombocytopenia can cause bleeding into the brain, which can be fatal.